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STEAP mRNA detection in serum of patients with solid tumours.  (2009)

Authors:
Valenti MT; Dalle Carbonare L; Donatelli L; Bertoldo F; Giovanazzi B; Caliari F; Lo Cascio V.
Title:
STEAP mRNA detection in serum of patients with solid tumours.
Year:
2009
Type of item:
Articolo in Rivista
Tipologia ANVUR:
Articolo su rivista
Language:
Inglese
Referee:
Name of journal:
Cancer Letters
ISSN of journal:
0304-3835
N° Volume:
273
Number or Folder:
1
Page numbers:
122-126
Keyword:
STEAP; cancer; serum
Short description of contents:
STEAP was identified by the strategy of suppression subtractive hybridizations in Los Angeles prostate cancer xenografts. It is expressed in prostate and other cancers, and not in most normal tissue; it can be used as a marker to evaluate biological samples from individuals suspected of having a disease associated with STEAP dysregulation, such as cancers, and may provide prognostic information useful in defining appropriate therapeutic options. The aim of this study was to test the STEAP mRNA detection in the serum of patients with different malignant tumours by using Real-Time reverse transcription PCR. The results were compared with biological samples obtained by age-matched non-malignant donors. Our data demonstrated that STEAP mRNA is detectable in serum of patients with different solid tumours whereas it is not amplifiable in non-malignant donors. This marker revealed with the molecular method of quantitative PCR in serum, may be useful to discriminate normal and cancer patients.
Product ID:
55091
Handle IRIS:
11562/323868
Deposited On:
July 14, 2012
Last Modified:
August 16, 2021
Attachments:
1
Bibliographic citation:
Valenti MT; Dalle Carbonare L; Donatelli L; Bertoldo F; Giovanazzi B; Caliari F; Lo Cascio V., STEAP mRNA detection in serum of patients with solid tumours. «Cancer Letters» , vol. 273 , n. 12009pp. 122-126

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Title Department Managers
Valutazione dell'RNA circolante in pazienti oncologici Department Medicina Maria Teresa Valenti
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