- Authors:
-
Diaz-Uriarte, Ramon; Gómez de Lope, Elisa; Giugno, Rosalba; Fröhlich, Holger; Nazarov, Petr V; Nepomuceno-Chamorro, Isabel A; Rauschenberger, Armin; Glaab, Enrico
- Title:
-
Ten quick tips for biomarker discovery and validation analyses using machine learning
- Year:
-
2022
- Type of item:
-
Articolo in Rivista
- Tipologia ANVUR:
- Articolo su rivista
- Language:
-
Inglese
- Referee:
-
No
- Name of journal:
- PLOS COMPUTATIONAL BIOLOGY
- ISSN of journal:
- 1553-7358
- N° Volume:
-
18
- Number or Folder:
-
8
- Page numbers:
-
1-17
- Keyword:
-
biomarker discovery, machine learning
- Short description of contents:
- High-throughput experimental methods for biosample profiling and growing collections of clinical and health record data provide ample opportunities for biomarker discovery and medical decision support. However, many of the new data types, including single-cell omics and high-resolution cellular imaging data, also pose particular challenges for data analysis. A high dimensionality of the data in relation to small numbers of available samples (often referred to as the p >> n problem), influences of additive and multiplicative noise, large numbers of uninformative or redundant data features, outliers, confounding factors and imbalanced sample group numbers are all common characteristics of current biomedical data collections. While first successes have been achieved in developing clinical decision support tools using multifactorial omics data, e.g., resulting in FDA-approved omics-based biomarker signatures for common cancer indications [1], there is still an unmet need and great potential for earlier, more accurate and robust diagnostic and prognostic tools for many complex diseases
- Product ID:
-
130817
- Handle IRIS:
-
11562/1080775
- Last Modified:
-
November 28, 2024
- Bibliographic citation:
-
Diaz-Uriarte, Ramon; Gómez de Lope, Elisa; Giugno, Rosalba; Fröhlich, Holger; Nazarov, Petr V; Nepomuceno-Chamorro, Isabel A; Rauschenberger, Armin; Glaab, Enrico,
Ten quick tips for biomarker discovery and validation analyses using machine learning
«PLOS COMPUTATIONAL BIOLOGY»
, vol.
18
, n.
8
,
2022
,
pp. 1-17
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