Publications

Authors:

Spinelli, Antonello E.; Boschi, Federico

Title:

Photodynamic therapy using Cerenkov and radioluminescence light

Year:

2021

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Format:

Elettronico

Referee:

Sì

Name of journal:

FRONTIERS IN PHYSICS

ISSN of journal:

2296-424X

N° Volume:

9

Number or Folder:

637120

Page numbers:

1-7

Keyword:

photodynamic therapy; Cerenkov radiation; radioluminescence; nano particles; photosensitizer

Short description of contents:

In this short review the potential use of Cerenkov radiation and radioluminescence as internal sources for Photodynamic therapy (PDT) is discussed. PDT has been developed over the course of more than 100 years and is based on the induced photo conversion of a drug called photosensitizer (PS) that triggers the production of cytotoxic reactive oxygen species (ROS) leading to the killing of the cells. In order to overcome the problem of light penetration in the tissues, different solutions were proposed in the past. The use of radioisotopes like: F-18, Cu-64, Y-90, Lu-177 as internal light sources increase the light fluence at the PS compared to an external source, resulting in a larger cytotoxic effect.

Web page:

https://doi.org/10.3389/fphy.2021.637120

Product ID:

124972

Handle IRIS:

11562/1057938

Last Modified:

November 18, 2022

Bibliographic citation:

Spinelli, Antonello E.; Boschi, Federico, Photodynamic therapy using Cerenkov and radioluminescence light «FRONTIERS IN PHYSICS» , vol. 9 , n. 637120 , 2021 , pp. 1-7

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