Publications

Authors:

Crescenzo, Francesco; Marastoni, Damiano; Pisani, Anna Isabella; Tamanti, Agnese; Dapor, Caterina; Colombi, Annalisa; Brillo, Alessandro; Magliozzi, Roberta; Pizzini, Francesca Benedetta; Castellaro, Marco; Calabrese, Massimiliano

Title:

The prognostic value of white-matter selective double inversion recovery mri sequence in multiple sclerosis: an exploratory study

Year:

2021

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Format:

Elettronico

Referee:

Sì

Name of journal:

DIAGNOSTICS

ISSN of journal:

2075-4418

N° Volume:

11

Number or Folder:

686

Page numbers:

1-12

Keyword:

DIR; MRI; double inversion recovery; multiple sclerosis; white matter

Short description of contents:

Using a white-matter selective double inversion recovery sequence (WM-DIR) that suppresses both grey matter (GM) and cerebrospinal fluid (CSF) signals, some white matter (WM) lesions appear surrounded by a dark rim. These dark rim lesions (DRLs) seem to be specific for multiple sclerosis (MS). They could be of great usefulness in clinical practice, proving to increase the MRI diagnostic criteria specificity. The aims of this study are the identification of DRLs on 1.5 T MRI, the exploration of the relationship between DRLs and disease course, the characterization of DRLs with respect to perilesional normal-appearing WM using magnetization transfer imaging, and the investigation of possible differences in the underlying tissue properties by assessing WM-DIR images obtained at 3.0 T MRI. DRLs are frequent in primary progressive MS (PPMS) patients. Amongst relapsing-remitting MS (RRMS) patients, DRLs are associated with a high risk of the disease worsening and secondary progressive MS (SPMS) conversion after 15 years. The mean magnetization transfer ratio (MTR) of DRLs is significantly different from the lesion without the dark rim, suggesting that DRLs correspond to more destructive lesions.

Web page:

https://doi.org/10.3390/diagnostics11040686

Product ID:

120920

Handle IRIS:

11562/1042894

Last Modified:

November 15, 2022

Bibliographic citation:

Crescenzo, Francesco; Marastoni, Damiano; Pisani, Anna Isabella; Tamanti, Agnese; Dapor, Caterina; Colombi, Annalisa; Brillo, Alessandro; Magliozzi, Roberta; Pizzini, Francesca Benedetta; Castellaro, Marco; Calabrese, Massimiliano, The prognostic value of white-matter selective double inversion recovery mri sequence in multiple sclerosis: an exploratory study «DIAGNOSTICS» , vol. 11 , n. 686 , 2021 , pp. 1-12

Consulta la scheda completa presente nel repository istituzionale della Ricerca di Ateneo