Pubblicazioni

Autori:

Crescenzo, Francesco; Marastoni, Damiano; Pisani, Anna Isabella; Tamanti, Agnese; Dapor, Caterina; Colombi, Annalisa; Brillo, Alessandro; Magliozzi, Roberta; Pizzini, Francesca Benedetta; Castellaro, Marco; Calabrese, Massimiliano

Titolo:

The prognostic value of white-matter selective double inversion recovery mri sequence in multiple sclerosis: an exploratory study

Anno:

2021

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Lingua:

Inglese

Formato:

Elettronico

Referee:

Sì

Nome rivista:

DIAGNOSTICS

ISSN Rivista:

2075-4418

N° Volume:

11

Numero o Fascicolo:

686

Intervallo pagine:

1-12

Parole chiave:

DIR; MRI; double inversion recovery; multiple sclerosis; white matter

Breve descrizione dei contenuti:

Using a white-matter selective double inversion recovery sequence (WM-DIR) that suppresses both grey matter (GM) and cerebrospinal fluid (CSF) signals, some white matter (WM) lesions appear surrounded by a dark rim. These dark rim lesions (DRLs) seem to be specific for multiple sclerosis (MS). They could be of great usefulness in clinical practice, proving to increase the MRI diagnostic criteria specificity. The aims of this study are the identification of DRLs on 1.5 T MRI, the exploration of the relationship between DRLs and disease course, the characterization of DRLs with respect to perilesional normal-appearing WM using magnetization transfer imaging, and the investigation of possible differences in the underlying tissue properties by assessing WM-DIR images obtained at 3.0 T MRI. DRLs are frequent in primary progressive MS (PPMS) patients. Amongst relapsing-remitting MS (RRMS) patients, DRLs are associated with a high risk of the disease worsening and secondary progressive MS (SPMS) conversion after 15 years. The mean magnetization transfer ratio (MTR) of DRLs is significantly different from the lesion without the dark rim, suggesting that DRLs correspond to more destructive lesions.

Pagina Web:

https://doi.org/10.3390/diagnostics11040686

Id prodotto:

120920

Handle IRIS:

11562/1042894

ultima modifica:

15 novembre 2022

Citazione bibliografica:

Crescenzo, Francesco; Marastoni, Damiano; Pisani, Anna Isabella; Tamanti, Agnese; Dapor, Caterina; Colombi, Annalisa; Brillo, Alessandro; Magliozzi, Roberta; Pizzini, Francesca Benedetta; Castellaro, Marco; Calabrese, Massimiliano, The prognostic value of white-matter selective double inversion recovery mri sequence in multiple sclerosis: an exploratory study «DIAGNOSTICS» , vol. 11 , n. 686 , 2021 , pp. 1-12

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