Computational biology (2014/2015)

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Course code
4S000524
Credits
6
Coordinator
Alejandro Giorgetti
Other available courses
Other available courses
    Academic sector
    BIO/10 - BIOCHEMISTRY
    Language of instruction
    Italian
    Teaching is organised as follows:
    Activity Credits Period Academic staff Timetable
    teoria 3 II sem. Alejandro Giorgetti
    laboratorio 3 II sem. Alejandro Giorgetti

    Lesson timetable

    Learning outcomes

    This course gives an introduction to molecular computational biology, from biomolecular simulation and to structural bioinformatics.

    Syllabus

    Part A – Bioinformatics

    − Advanced Structural Bioinformatics
    - Thermodynamic basis of the stability of folded biomolecular structure
    − Molecular basis of human perception


    Part B – Molecular Modeling

    − Basic elements of molecular modeling
    − Electrostatic modeling
    − Energy minimization based on force fields
    − Molecular dynamics: solution by using the open source NAMD and/or Gromacs codes
    − Conformational analysis


    Part C – Ligand-prtoein interactions


    − Protein assembly (protein-protein complexes, protein-protein interactions in protein dimers, crystals): protein-protein docking algorithms and programs
    − Ligand Protein interaction: docking algorithms and programs
    − Projects: Drug and/or protein design

    Assessment methods and criteria

    Written

    Teaching aids
    Title Format (Language, Size, Publication date)
    ligando  octet-streamoctet-stream (it, 2 KB, 18/05/15)
    proteina  octet-streamoctet-stream (it, 102 KB, 18/05/15)
    slides-dock  pdfpdf (it, 2872 KB, 18/05/15)
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