Pubblicazioni

Autori:

Pedrinolla, Anna; Venturelli, Massimo; Tamburin, Stefano; Fonte, Cristina; Maria Stabile, Anna; Boscolo Galazzo, Ilaria; Ghinassi, Barbara; Anna Venneri, Mary; Pizzini, Francesca Benedetta; Muti, Ettore; Smania, Nicola; Di Baldassarre, Angela; Naro, Fabio; Rende, Mario; Schena, Federico

Titolo:

Non-Aβ-dependent factors associated with global cognitive and physical function in Alzheimer’s Disease: a pilot multivariate analysis

Anno:

2019

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Lingua:

Inglese

Formato:

Elettronico

Referee:

Sì

Nome rivista:

JOURNAL OF CLINICAL MEDICINE

ISSN Rivista:

2240-0109

N° Volume:

8

Numero o Fascicolo:

2

Intervallo pagine:

224-1-224-12

Parole chiave:

Alzheimer’s disease; mild cognitive impairment; dementia; exercise; memory; physical activity

Breve descrizione dei contenuti:

Recent literature highlights the importance of identifying factors associated with mild cognitive impairment (MCI) and Alzheimer’s Disease (AD). Actual validated biomarkers include neuroimaging and cerebrospinal fluid assessments; however, we investigated non-Aβ-dependent factors associated with dementia in 12 MCI and 30 AD patients. Patients were assessed for global cognitive function (Mini-Mental state examination—MMSE), physical function (Physical Performance Test—PPT), exercise capacity (6-min walking test—6MWT), maximal oxygen uptake (VO2max), brain volume, vascular function (flow-mediated dilation—FMD), inflammatory status (tumor necrosis factor—α ,TNF- α, interleukin-6, -10 and -15) and neurotrophin receptors (p75NTR and Tropomyosin receptor kinase A -TrkA). Baseline multifactorial information was submitted to two separate backward stepwise regression analyses to identify the variables associated with cognitive and physical decline in demented patients. A multivariate regression was then applied to verify the stepwise regression. The results indicated that the combination of 6MWT and VO2max was associated with both global cognitive and physical function (MMSE = 11.384 + (0.00599 × 6MWT) − (0.235 × VO2max)); (PPT = 1.848 + (0.0264 × 6MWT) + (19.693 × VO2max)). These results may offer important information that might help to identify specific targets for therapeutic strategies (NIH Clinical trial identification number NCT03034746).

Pagina Web:

https://doi.org/10.3390/jcm8020224

Id prodotto:

106804

Handle IRIS:

11562/991325

ultima modifica:

15 novembre 2022

Citazione bibliografica:

Pedrinolla, Anna; Venturelli, Massimo; Tamburin, Stefano; Fonte, Cristina; Maria Stabile, Anna; Boscolo Galazzo, Ilaria; Ghinassi, Barbara; Anna Venneri, Mary; Pizzini, Francesca Benedetta; Muti, Ettore; Smania, Nicola; Di Baldassarre, Angela; Naro, Fabio; Rende, Mario; Schena, Federico, Non-Aβ-dependent factors associated with global cognitive and physical function in Alzheimer’s Disease: a pilot multivariate analysis «JOURNAL OF CLINICAL MEDICINE» , vol. 8 , n. 2 , 2019 , pp. 224-1-224-12

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