Potenziale aritmogenico dei farmaci (ARITMO)

Data inizio
1 gennaio 2010
Durata (mesi) 
36
Dipartimenti
Diagnostica e Sanità Pubblica
Responsabili (o referenti locali)
Moretti Ugo
URL
http://www.aritmo-project.org/
Parole chiave
torsade des pointes, QT prolongation, pharmacovigilance

The ability of some compounds to prolong the QT interval of the electrocardiogram and to precipitate Torsade de Pointes (TdP, a potentially fatal arrhythmia) has caused several regulatory interventions, including drug withdrawals. Specific guidelines have been implemented to detect QT liability of new compounds as early as possible.
However there is growing evidence that an increase in the QT interval does not necessarily lead to TdP which further increased the regulatory and clinical difficulties. This project will assess the arrhythmogenic potential of antipsychotics, antihistamines and anti-infectives (> 250 compounds). It will fulfill this aim by: reviewing the literature on in-vitro and in-vivo preclinical evidence; conducting in-silico modeling to predict the arrhythmic potential through target profiling and docking molecules in existing atomistic models and predicting the effects on hERG K+, Na+, Ca++ channels; analyzing the information in national and international pharmacovigilance DBs of spontaneous reports; conducting prospective case control surveillance on symptomatic QT prolongation; conducting cohort studies in psychiatric and hematology patients; analyzing information from existing studies to assess the association between drug use and various arrhythmia outcomes; and collecting blood samples from cases and drug-matched controls to investigate potential effect modification by candidate genes and a hypothesis generating approach including more than 2000 genes. Healthcare DBs on 27 million persons in 5 countries will be used to calculate rates and relative risks of arrhythmic events during drug use. Predictions on arrhythmic potential will be compared with actual postmarketing risk to assess the predictive value of preclinical markers.
All information will be integrated to allow for ranking the arrhythmic potential of all the 250 study drugs and creation of risk charts that will allow for more informed treatment and decision making.

Enti finanziatori:

Commissione europea – VII PQ
Finanziamento: assegnato e gestito dal dipartimento
Programma: EUROPA - Progetti Europei

Partecipanti al progetto

Anita Conforti
Cultore della materia
Roberto Leone
Professore associato
Pubblicazioni
Titolo Autori Anno
Antimicrobials and the Risk of Torsades de Pointes: The Contribution from Data Mining of the US FDA Adverse Event Reporting System Poluzzi E.; Raschi E.; Motola D.; Moretti U.; De Ponti F. 2010

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